Dr. Hans Raj Bhat

Dr. Hans Raj Bhat
Dr. Hans Raj Bhat
...
Assistant Professor
Pharmaceutical Science

Profile

Education:

  1. Bachelor’s Degree: B. Pharm Mohanlal Sukhadia University, Udaipur, Rajasthan 2005
  2. Master’s Degree: M.Pharm Dibrugarh University, Assam, 2008
  3. Ph.D.: Pharmaceutical Sciences Dibrugarh University, Assam, 2014
  4. Other:
    1. GATE 2006 IIT Kharagpur
    2. GATE 2007 IIT Kanpur

 

Professional Experience: 8.1 Years

 

Areas of Interest/ Specialization:

  • Medicinal Chemistry, Antimalarial Drug Development

 

Publications

Research Publications:

Article Published:

           

  •     Shakya A., Bhat H.R., Ghosh S.K. (2017) Update on Nitazoxanide: A Multifunctional Chemotherapeutic Agent.Curr Drug Discov Technol.ISSN: 1570-1638. Doi: 10.2174/1570163814666170727130003

  •    Kashyap A., Adhikari N., Das A., Shakya A., Ghosh S.K., Singh U.P., Bhat H.R. (2017)Review on Synthetic Chemistry and Antibacterial Importance of Thiazole Derivatives. Curr Drug Discov Technol.ISSN: 1570-1638. DOI: 10.2174/1570163814666170911144036

  •    Shrivastava J.K., Pillai G.G., Bhat H.R., Verma A.,Singh U.P. (2017) Design and discovery of novel monastrol-1,3,5-triazines as potent anti-breast cancer agent via attenuating Epidermal Growth Factor Receptor tyrosine kinase. Nature Sci. Rep. 7: 5851. doi:10.1038/s41598-017-05934-5.  ISSN 2045-2322 (IF-5.22)

  •    Singh U.P., Shrivastava J.K., Verma A., Bhat H.R. (2017) Targeting immune and non-immuno synovitis by 1,3,5-TRIAZINE-THIAZOLE via dual inhibition of NF-KB and EGFR-TKS for possible benefit in rheumatoid arthritis. Annals of the Rheumatic Diseases. 76(2) 1072-1073.ISSN:0003-4967 (IF-12.811)

  •    Singh U.P., Shrivastava J.K., Verma A., Bhat H.R. (2017)Discovery of 1,3,5-triazine-monastrol based novel EGFR-tyrosine kinase inhibitor against human lung carcinoma. Annals of Oncology. 28(2): ii9-ii13. ISSN: 1569-8041 (IF-9.26)

  •     Singh UP, Srivastava JK, Bhat HR (2017) Novel monastrol derivatives exert potent anti-breast cancer activity via inhibition of ubiquitin conjugating enzyme Rad6B.European Journal of Cancer.72(1): S36–S37.ISSN: 0959-8049 (IF-6.16).

  •   Singh UP, Bhat HR (2017) PUB081 Discovery of 1,3,5-Triazine Based Novel EGFR-Tyrosine Kinase Inhibitor against Human Lung Carcinoma. Journal of Thoracic Oncology. 12 (1): S1494–S1495. ISSN: 1556-0864 (IF-5.04).

  •      Bhat, HR , Singh, UP,  Yadav, PS,  Kumar, V, Gahtori, P., Das A., Chetia, D., Prakash, A., Mahanta, J. (2016) Synthesis, characterization and antimalarialactivity of hybrid4-aminoquinoline-1,3,5-triazinederivatives. Arabian J. Chem., 2016; 9: S625-S631. (IF- 3.61) ISSN: 1878-5352

  •      Singh UP, Srivastava JK, Bhat HR (2016) Discovery of novel 1,3,5-triazine-thiourea based dual PI3K/ mTOR inhibitor against Non-small cell lung cancer (NSCLC). Annals of Oncology 27(9):50. (IF- 9.26) ISSN: 1569-8041

  •     Sahu S, Ghosh SK, Kalita J, Dutta M, Bhat HR (2016) Design, synthesis and antimalarial screening of some hybrid 4-aminoquinoline-triazine derivatives against pf-DHFR-TS. Exp Parasitol.163:38-45. (IF- 1.85) ISSN: 1090-2449.

  •     Singh UP, Srivastava JK, Bhat HR (2015) Structure-based optimization and discovery of novel 1,3,5-triazine derivatives as bacterial translation inhibitor with favourable metabolic fate. Antimicrob Resist Infect Control., 2015; 4(Suppl 1): I2.

  • Srivastava JK, Awatade NT, Bhat HR, Kmit A, Mendes K, Ramos M, Amaral MD, Singh UP (2015) Pharmacological evaluation of hybrid thiazolidin-4-one-1,3,5-triazines for NF-κB, biofilm and CFTR activity. RSC Adv., 5, 88710-88718.
  • Bhat HR, Singh UP, Thakur A, Ghosh SK, Gogoi K, Prakash A, Singh RK (2015) Synthesis, antimalarial activity and molecular docking of hybrid 4-aminoquinoline-1,3,5-triazine derivatives. Exp Parasitol.157, 59-67. DOI:10.1016/j.exppara. 2015.06.016 (IF- 1.85)
  • Singh JK, Dubey P, Singh S, Bhat HR, Kumawat MK, Singh UP, (2015) Discovery of novel 1,3,5-triazine-thiazolidine-2,4-diones as dipeptidyl peptidase-4 (DPP-4) inhibitor targeting S1 pocket for the treatment of type 2 diabetes along with antibacterial activity. RSC Adv ,5, 14095-14102. (IF- 3.70)
  • Bhat HR, Singh UP, Gahtori P, Ghosh SK, Gogoi K, Prakash A, Singh RK (2015) Synthesis, docking, in vitro and in vivo antimalarial activity of hybrid 4-aminoquinoline-1,3,5-triazine derivatives against wild and mutant malaria parasites, Chemical Biology & Drug Design, DOI: 10.1111/cbdd.12490. (IF- 2.50)
  • Singh B, Bhat HR, Kumawat MK, Singh UP (2014) Structure-guided discovery of 1,3,5-triazine-pyrazole conjugates as antibacterial and antibiofilm agents against pathogens causing human diseases with favourable metabolic fate. Bioorganic & Medicinal Chemistry Letters, 24, 3321-3325, DOI: 10.1016/j.bmcl.2014.05.103 (IF- 2.42)
  • Bhat HR, Singh UP, Gahtori P, Ghosh SK, Gogoi K, Prakash A, Singh RK. (2014). 4-Aminoquinoline-1,3,5-triazine: Design, synthesis, in vitro antimalarial activity and docking studies.ChemInform Abstract, 45, DOI: 10.1002/chin.201404181
  • Pathak P, Thakur A, Bhat HR, Singh UP (2014) Hybrid 4-Aminoquinoline-1,3,5-triazine Derivatives: Design, Synthesis, Characterization, and Antibacterial Evaluation, Journal of Heterocyclic Chemistry, DOI 10.1002/jhet.2210 (IF- 0.78)
  • Singh UP, Bhat HR, Verma A, Kumawat MK, Singh RK (2013) Phenylhydrazone bearing pyrazole and pyrimidine scaffolds: Design and discovery of novel class of Non-nucleoside Reverse Transcriptase Inhibitor (NNRTIs) and antibacterial agent. RSC Adv., 3:17335-17348. DOI: 10.1039/C3RA41604F (IF- 3.70)
  • Singh UP, Bhat HR, Kumawat MK, Singh RK. (2013) Utilisation of Home Laundry Effluent (HLE) as a catalyst for the expeditious one-pot aqueous phase synthesis of highly functionalised 4-thiazolidinones. SpringerPlus., 2:466. DOI:10.1186/2193-1801-2-466.
  • Bhat HR, Singh UP, Gahtori P, Ghosh SK, Gogoi Kabita, Prakash A, Singh RK. (2013). 4-Aminoquinoline-1,3,5-triazine:Design, synthesis, in vitro antimalarial activity and docking studies. New J. Chem.,37: 2654-2662. DOI: 10.1039/C3NJ00317E.(IF-3.15)
  • Bhat H.R., Kumar P., Ghosh S.K., Singh U.P. (2013) Development of 4-aminoquinoline-1,3,5-triazine conjugates as potent antibacterial agent through facile synthetic route. Med Chem Res., 22:5056-5065. DOI:10.1007/s00044-013-0521-8 (IF-1.62)
  • Kumar S, Bhat HR, Kumawat MK, Singh UP. (2013) Design and one-pot synthesis of hybrid thiazolidin-4-one-1,3,5-triazines as potent antibacterial agent against human disease causing pathogens. New J. Chem., 37:581-584. DOI: 10.1039/C2NJ41028A (IF-3.15)
  • Bhat H.R., Singh U.P., Gahtori P., Ghosh S.K., Gogoi K., Prakash A., Singh R.K. (2013) Antimalarial activity and docking studies of novel bifunctional hybrids derived from 4-aminoquinoline and 1,3,5- triazine against wild and mutant malaria parasites as pf-DHFR inhibitor. RSC Adv., 3:2942-2952. DOI: 10.1039/C2RA21915H (IF- 3.70)
  • Singh UP, Bhat HR, Gahtori P, Singh RK. (2013) Hybrid thiazole-1,3,5-triazines target cytosolic Leucyl-tRNA synthetase for antifungal action revealed by molecular docking studies. In Silico Pharmacology, 1: 3. DOI:10.1186/2193-9616-1-3
  • Singh UP, Bhat HR, Singh RK. (2013) Ceric ammonium nitrate catalysed expeditious one-pot synthesis of 1,3-thiazine as IspE kinase inhibitor of Gram-negative bacteria using polyethylene glycol (PEG-400) as an efficient recyclable reaction medium. C.R.Chim., 16:462-468. DOI: 10.1016/j.crci.2012.11.019 . (IF-1.48)
  • Bhat H.R., Gupta, S.K., Singh U.P. (2012) Discovery of potent, novel antibacterial hybrid conjugates from4-aminoquinoline and 1,3,5-triazine: design, synthesis and antibacterial evaluation. RSC Adv.,2: 12690–12695. DOI: 10.1039/C2RA22353H (IF- 3.70)
  • Dubey V, Pathak M, Bhat HR, Singh UP (2012) Design, Facile Synthesis, and Antibacterial Activity of Hybrid 1,3,4-thiadiazole-1,3,5-triazine Derivatives Tethered via -S- Bridge.Chem Biol Drug Des., 80(4):598-604. DOI:10.1111/j.1747-0285.2012.01433.x. (IF- 2.50)
  • Singh UP, Pathak M, Dubey V, Bhat HR, Gahtori P, Singh RK. (2012) Design, Synthesis, Antibacterial Activity, and Molecular Docking Studies of Novel Hybrid 1,3-Thiazine-1,3,5-Triazine Derivatives as Potential Bacterial Translation Inhibitor.Chem Biol Drug Des., 80:572-83. DOI:10.1111/j.1747-0285.2012.01430.x (IF- 2.50)
  • Singh, U.P., Bhat, H.R., Gahtori, P. (2012) Antifungalactivity, SAR and physicochemicalcorrelation of some thiazole-1,3,5-triazinederivatives. Journal de Mycologie Médicale. 22:134–141. (IF- 0.4)
  • Gahtori P, Ghosh SK, Parida P, Prakash A, Gogoi K, Bhat HR, Singh UP. (2012) Antimalarial evaluation and docking studies of hybrid phenylthiazolyl-1,3,5-triazine derivatives: a novel and potential antifolate lead for Pf-DHFR-TS inhibition.Exp Parasitol. 130:292-299.(IF- 1.85)
  • Gahtori, P., Ghosh, S.K., Singh, B., Singh, U.P., Bhat, H.R., Uppal, A., (2012) Synthesis, SAR and antibacterial activity of hybrid chloro, dichloro-phenylthiazolyl-striazines. Saudi Pharm J., 20:35–43.   (IF- 1.00)
  • Bhat HR, Ghosh SK, Prakash A, Gogoi K, Singh UP. (2012) In vitro antimalarial activity and molecular docking analysis of 4-aminoquinoline-clubbed 1,3,5-triazine derivatives. Lett Appl Microbiol., 54:483-486. (IF- 1.74)
  • Ghosh, S.k; Saha, A; Hazarika, B; Singh, UP; Bhat, HR; Gahtori, P. (2012) Design, Facile Synthesis, Antibacterial Activity and Structure-Activity Relationship of Novel Di- and Tri-Substituted 1,3,5-Triazines. Letters in Drug Design & Discovery., 9:329-335. (IF- 0.96)
  • Yadav PS, Kumar, V, Singh UP, Bhat, HR, Mazumder B (2012) Physicochemical characterization and in vitro dissolution studies of solid dispersions of ketoprofen with PVP K30 and d-mannitol. Saudi Pharm J.,21:77-84.
  • Bhat, HR, Singh, UP, Yadav, PS, Kumar, V, Gahtori, P., Das A., Chetia, D., Prakash, A., Mahanta, J. (2011) Synthesis, characterization and antimalarialactivity of hybrid4-aminoquinoline-1,3,5-triazinederivatives. Arabian J. Chem., doi.org/10.1016/j.arabjc.2011.07.001. (IF- 2.68)
  • Singh UP, Singh RK, Bhat HR, Subhashchandra YP, Kumar V, Kumawat MK, et al. (2011) Synthesis and antibacterial evaluation of series of novel tri-substituted-s-triazine derivatives. Med Chem Res., 20:1603-1610. (IF- 1.62)
  • Kumar V, Yadav PS, Singh UP, Bhat HR, Zaman K, Ali M (2011) Isolation of new racemicsugar (D/L galacturonic acid) from leaves of Paederia foetida Linn. Nature Preceedings. DOI: 10.1038/npre.2011.5752.1
  • Kumar V, Yadav PS, Singh UP, Bhat HR, Rana A, Kamaruz ZM (2010)Pharmacognostical evaluation of Cuscuta reflexa Roxb.Phcog J., 2:74-82.
  • Kumar V., Yadav P.S., Singh U.P., Bhatt H.R., Zaman K. (2009) Pharmacognostical and Phytochemical study on Leaves of Peaderia foetida linn. International Journal of PharmTech Research1; 3:918-920.
  • Kumar P., Bhat H.R., DasA. (2008) Synthesis of N-[4'-(4''-substituted Phenyl)-thiazol-2'-yl]-[1,3,5]-triazine-2-amine series as novel antibacterial agents Indian J. Pharm. Sci., 7(2) 107-111. DOI: 10.4103/0250-474X.51960 (IF-0.29)

 

Abstracts Published in Proceedings’:

  • Bhat H.R. Ghosh, S.K, Shakya, A, Singh, U.P. Design, Synthesis and Antibacterial Evaluation of hybrid 4-aminoquinoline Triazine Derivatives. National Seminar on ‘Natural Resources for Drug Discovery and Development’. Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India. February 24-25, 2018: 19.
  • Shakya, A., Bhat, H.R., Ghosh, S.K. A Report on Phytotherapeutic aspect of Benincasa hispida (Thunb.) National Seminar on ‘Natural Resources for Drug Discovery and Development’. Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, India. February 24-25, 2018: 40.
  • Bhat H.R. Ghosh, S.K, Shakya, A, Singh, U.P. Design, Synthesis and Antimalarial Evaluation of Tri-substituted 1,3,5-Triazine Derivatives. International symposium on contemporary facets in organic synthesis 2017 (CFOS2017) at IIT Roorkee, India. December 22-24, 2017.
  • Shakya, A., Mahanta, S., Bhat, H.R., Ghosh, S.K. Protective effect of the Acmella paniculata against ethanol induced liver and stomach pathologies: a preclinical study. Conference proceedings of 7th Euro-India International Conference on Holistic Medicine (ICHM-2017): Kottayam, Kerala, India. September 15-17, 2017.
  • Shakya, A., Mahanta, S., Bhat, H.R., Ghosh, S.K. Protective effect of the Acmella paniculata against ethanol induced liver and stomach pathologies: a preclinical study. 7th Euro-India International Conference on Holistic Medicine (ICHM-2017): Kottayam, Kerala, India. September 15-17, 2017.
  • Bhat H.R., SinghU.P., Ghosh S.K.Synthesis and antibacterial and antifungal evaluation of Novel 4-Aminoquinoline semicarbazide conjugates.National Conferences onEmerging Trends in Pharmaceutical & Biotechnological Research at Anand college of pharmacy Agra, India, November 06-07, 2015.
  • Singh U.P., Srivastava J.K., Bhat H.R. Discovery of Novel Diaryltriazines (DATAs) as Non-nucleoside Reverse Transcriptase inhibitors via Extension into the Entrance channel of HIV-1 Reverse Transcriptase. international conferences on 15th European Aids Conference, Barcelona, Spain 21-24 October 2015. PE10/1 PP. 180.
  • Verma A., Bhat H.R., Singh U.P., Design and Discovery of potent Hybrid 1,3,5-triazines-1,3-Thiazine Analogs Clubbed via Amide Bridge: A Novel Lead for next generation NNRTI. International conferences on 15th European Aids Conference, Barcelona, Spain 21-24 October 2015. PE10/2 PP. 181.
  • Oral Presentation on the topic of “Design, synthesis and antimalarial activity of Hydrid 4-aminoquinoline 1,3,5-triazine derivatives” International workshop on the topic “Discovery of new drugs against Malaria” at International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi from 27th January to 6th February 2015.
  • Bhat H.R., Singh U.P., Gahtori P., Ghosh S.K., Prakash A., Kavita K., Singh R.K. Hybrid 4-aminoquinoline-1,3,5-triazine derivatives: Design, synthesis, in-vitro antimalarial activity and docking studies against wild & mutant malaria parasites. National conferences on chemistry at the interface of innovative researches in sciences & technology at university of Allahabad. India, Feb 27-28, 2014, P-41, 42.
  • Singh B., Bhat H.R., Kumawat M.K., Singh U.P. Structure-guided synthesis of 1,3,5-triazine–pyrazole conjugates as potent antibacterial and antibiofilm inhibitory activity against pathogens causing human diseases with favorable metabolic fate.National conferences on chemistry at the interface of innovative researches in sciences & technology at university of Allahabad. India, Feb 27-28, 2014, P- 40.
  • Bhat H.R., Singh U.P., Yadav P.K., Ghosh S.K., Prakash A., Mahanta J. Synthesis and Molecular Docking Studies of Hybrid 4-aminoquinoline s-triazines. International Conference on MedChem 2011 at IICT/NIPER Hyderabad. India, Feb 25 and 26, 2011, P-14
  • Singh U.P., Bhat H.R., Pathak M.K., Dubey V., Yadav P.K., Singh R.K., (2011) Molecular Docking Studies of Hybrid 1,3-thiazine-s-1,3,5-triazene Derivatives Against r-RNA: Novel Bacterial Translation Inhibitors. International Conference on MedChem 2011 at IICT/NIPER Hyderabad. India, Feb 25 and 26, 2011, P-12
  • Singh U.P., Bhat H.R., Kumar V., Yadav P. S., Chetia D., Ghosh S. K. “Herpes simplex virus - Antiviral drug resistance” National Conference on Emerging Trends in Pharmaceutical Sciences, Jammu University, Shrinagar, Jammu, 8-9 March 2009.
  • Bhat H.R., Kumar V., Gahtori P., Das A., Chetia D., PrakashA., MahantaJ. Synthesis and Antimalarial activity evaluation of some analogues of 7-chloro-N-[3-(4,6-diamino-1,3,5-triazin-2-ylamino) propyl]quinoline-4-amine derivatives. Antimicrobial Resistance: From Emerging Threat to Reality from 23rd-25th March, 2009, at Allahabad Agricultural Institute-Deemed University, Sponsored by WHO, ICAR, ICMR, DST, NABARD, Govt. of India.
  • Gahtori P., Bhat H.R., Ghosh S.K., Singh B. Antimalarial Drug Resistance need of multiple drug therapy.Antimicrobial Resistance: From Emerging Threat to Reality from 23rd-25th March, 2009, at Allahabad Agricultural Institute-Deemed University, Sponsored by WHO, ICAR, ICMR, DST, NABARD, Govt. of India
  • Kumar V., Bhat H.R., Zaman K. In vitro antioxidant properties of Paederia foetida Linn leaf extract. National Seminar on Recent Advances in Chemical Sciences, Dibrugarh University, Dibrugarh 26-27 March 2009.
  • Kumar V., Bhat H.R., Kumar V. Drugs For Sprotsman. National Seminar On Emerging Trends In Noval Drug Delivery System. H.R. Institute Of Pharmacy, Ghaziabad, 27-28 March 2009.
  • Bhat H.R., Kumar V., Gahtori P., Das A., Chetia D., Prakash A., Mahanta J. Synthesis and Antimalarial activity evaluation of 2, 4, 6-trisubstituted traizine derivative. National Conference on Recent Trends in Pharmaceutical Sciences, Anand college of pharmacy Agra 14-15 November, 2009.
  • Yadav P.S., Kumar V., Singh U.P., Bhat H.R., Ahmed D., Mazumder B. Physicochemical characterisation and in-vitro dissolution studies of solid dispersion of Ketoprofen with PVP K30 and D-Mannitol. 97th Indian Science Congress, Trivandrum, 3-7 January, 2010.
  • Kumar V., Yadav P.S., Singh U.P., Bhat H.R., Ahmed D. Review: Method for Evaluation of in-vitro and in-vivo Antioxidant Activity. 97th Indian Science Congress, Trivandrum, 3-7 January, 2010.
  • Ahmed D., Singh U.P., Kumar V., Yadav P.S., Bhat H.R., Effect of Rosiglitazone, Atorvastatin and Glimipride on Glycemic control and Lipid Profile on STZ induced NIDDM rats. 97th Indian Science Congress, Trivandrum, 3-7 January, 2010.
  • Kaithwas G., Singh U.P., Yadav P.S., Kumar V., Bhat H.R., Ahmed D. Diagnosis of Filarial Parasites. 97th Indian Science Congress, Trivandrum, 3-7 January, 2010.
  • Bhat H.R., Singh U.P., Yadav P.S., Kumar V., Gahtori P., Das A., Chetia D., Prakash A., Mahanta J. Synthesis and Antimalarial activity evaluation of some analogues of 7-chloro-N-[3-(4,6-diamino-1,3,5-triazin-2-ylamino) propyl] quinoline-4-amine derivatives. (Accepted for poster presentation,4th international Symposium on Current trends in drug discovery research Lucknow 17-21 Feb. 2010)
  • Singh U.P., Bhat H.R., Yadav P.S., Kumar V, Kumawat M.K., Gahtori P. synthesis and antibacterical evaluation of series of noval tri-substituted s-triazine derivatives. (Accepted for poster presentation, 4th international Symposium on Current trends in drug discovery research Lucknow 17-21 Feb. 2010)

 

·          Singh UP, Srivastava JK, Bhat HR (2016) Discovery of novel 1,3,5-triazine-thiourea based dual PI3K/ mTOR inhibitor against Non-small cell lung cancer (NSCLC). Annals of Oncology 27(9):50. (IF- 9.26) ISSN: 1569-8041

·          Bhat, HR , Singh, UP,  Yadav, PS,  Kumar, V, Gahtori, P., Das A., Chetia, D., Prakash, A., Mahanta, J. (2016) Synthesis, characterization and antimalarialactivity of hybrid4-aminoquinoline-1,3,5-triazinederivatives. Arabian J. Chem., 2016; 9: S625-S631. (IF- 3.61) ISSN: 1878-5352

·          Sahu S, Ghosh SK, Kalita J, Dutta M, Bhat HR (2016) Design, synthesis and antimalarial screening of some hybrid 4-aminoquinoline-triazine derivatives against pf-DHFR-TS. Exp Parasitol.163:38-45. (IF- 1.85) ISSN: 1090-2449.

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